My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. My husband said , get dressed were taking him in . I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. Was hospitalized for 2 1/2 days. Neurologist doesnt seem to really know if the effects are long term or not. Then he came too . She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). Side effects with Simparica are not common. If she recovers, cause is the Simparica. Now, here we are one month later and I just gave him the second dose about two hours ago. He has no appetite. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. Im beside myself with guilt and fear. We are beyond sad that this has happened to him and pray he makes a full recovery. All went well until this morning. Another call to vet asking for an appt - seems like an an emergency now? Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. I wanted to investigate a bit before dosing him. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. I did and they said they are going to report it to the FDA. My Lab mix has had 2 doses of this med. He has been low energy since. This seemed like perfect treatment 3 in 1 but at what cost? I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. Since then I've researched loads and as you say the FDA put out a report. and you expect people to give this to their beloved pets? We are currently going through this with our nine year old dachshund. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. He lays on his bed tucked far in the corner. Simparica 48. Hi, how much charcoal did you administer? My miniature Dash hound did not pull out. Its been 3 months and she continues to have them. My dog died from it after one dose within 24 hours. Also what are you looking at giving your dog as a seizure medication?? She is still in the vet since 3am. Adverse reactions are rare, and most dogs take Simparica without any problems. Was prescribed Simparica Trio for my Catahula dog with no medical issues. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Unfortunately, I didn't realize the tremors were possibly caused by the drug. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. Product Description. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. Two weeks after I made the post above our girl started having seizures and we had to put her down. It has been 20 days since I gave her the prescribed dose of Simparica. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. Our baby isnt the same at all since his one and only dose of Simparica. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. Pharmaceuticals are killing people and pets. Random vomitting is no fun either. Im wondering if there is any correlation as we havent changed anything else with him. No way I will ever give it to her again. Im petrified after reading the comments here. I bought chicken last night he ate some of that . Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. I rescued a dog that had a light case of heartworms. Oh Lord, back to finding another vet. She couldnt walk straight anymore and stopped eating. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. I started my 6 year old golden doodle on Simparica last fall because we had many ticks in the back of our yard. (toy aussie & corgi). She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . Has there been any improvement if so how long after did it take ? He is fully housebroken and just had a running stool accident in the house. It started working on him right away, Diarrhea. and to only let him out on a leash to go potty. He has been drinking more water then usual. He wasnt throwing up at all until he received this medication. Each month he got sicker and sicker. How can you give a dog a pesticide to ingest. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. four times. Buddy 8 year old male Boxer formerly energetic and playful. No more itching but covered in same scabs. If your dog has reactions to this medicine, push fluids! Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Bentlee has been fine for 12 + hours in the house while I was stuck at work and never a drop of anything in the house. Clinical Pharmacology Somedays he will have 2 and then he will go for a couple days without having any issues. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. In very rare instances, mild side effects and irritations can occur for a short period of time. I took my dog to the vet today and she received fluids and gabapentin. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. Omg, this is beyond awful and makes me so worried. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. We took him to vet and they gave nausea meds and kept him overnight. Today June 1,2022 she is still having neurological problems. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. Did anyone see any signs of improvement in their dogs? For the vast majority of . After reading all these posts that sound so similar to what we are going through. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. So no Addisions. Hi, Im wondering whats going on with your dog now? Shes now in the Er. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. These dog training tips will help you get started. Barely eats, but is drinking lots of water. like she wants me to fix it. My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. If anyone has discovered what can help please let me know. I gave my dog simparica at 10:15am. Are their enough people to file a class action suit? We just brought him home from hospital today. He wouldnt survive surgical attempt to go in and try to figure out what was going on. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. My vet prescribed my 16 week old puppy this drug because of a skin irritation. I'm not going to make her a test case by giving her another dose next month. This medication is generally well tolerated in most pets. He now cannot go in the car anymore. No more of this junk for my pups! She falls when she runs and when going up and down stairs. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. I wish I had seen this post first. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. The third ingredient in Simparica Trio is. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Snores like a big dog. Some had fleas, some had heartworms, and some had roundworms. 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